Selected article for: "cell killing and tumor cell"
Author: Capitani, Nagaja; Patrussi, Laura; Baldari, Cosima T.
Title: Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment
  • Cord-id: d5dje6xz
  • Document date: 2021_10_18
    • ID: d5dje6xz
    Snippet: Similar to Janus, the two-faced god of Roman mythology, the tumor microenvironment operates two opposing and often conflicting activities, on the one hand fighting against tumor cells, while on the other hand, favoring their proliferation, survival and migration to other sites to establish metastases. In the tumor microenvironment, cytotoxic T cells—the specialized tumor-cell killers—also show this dual nature, operating their tumor-cell directed killing activities until they become exhauste
    Document: Similar to Janus, the two-faced god of Roman mythology, the tumor microenvironment operates two opposing and often conflicting activities, on the one hand fighting against tumor cells, while on the other hand, favoring their proliferation, survival and migration to other sites to establish metastases. In the tumor microenvironment, cytotoxic T cells—the specialized tumor-cell killers—also show this dual nature, operating their tumor-cell directed killing activities until they become exhausted and dysfunctional, a process promoted by cancer cells themselves. Here, we discuss the opposing activities of immune cells populating the tumor microenvironment in both cancer progression and anti-cancer responses, with a focus on cytotoxic T cells and on the molecular mechanisms responsible for the efficient suppression of their killing activities as a paradigm of the power of cancer cells to shape the microenvironment for their own survival and expansion.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activation inhibit: 1, 2
    • absence presence and activity survival: 1, 2
    • absence presence and adaptive innate: 1, 2
    • absence presence and adhesion molecule: 1, 2, 3, 4
    • absence presence and local concentration: 1
    • absence presence and local invasion: 1
    • absence presence and low immune cell: 1
    • absence presence and lung cancer: 1, 2, 3, 4
    • absence presence and lung carcinoma: 1
    • absence presence and lysine residue: 1
    • absence presence and lysosomal origin: 1