Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_15
Snippet: Genomic comparison of 591 hCoV sequences among the human as well as with pangolin-hCoV and bat-hCoV revealed several sites possessing substitutions which clearly indicated the mutation in viral genome either according to the geographical locations or upon interaction with the human immune system. A detailed investigation of the nucleotide substitution in the coding region of hCoVs genome with perspective of encoded amino acids revealed 43 synonym.....
Document: Genomic comparison of 591 hCoV sequences among the human as well as with pangolin-hCoV and bat-hCoV revealed several sites possessing substitutions which clearly indicated the mutation in viral genome either according to the geographical locations or upon interaction with the human immune system. A detailed investigation of the nucleotide substitution in the coding region of hCoVs genome with perspective of encoded amino acids revealed 43 synonymous and 57 non-synonymous substitutions ( Table 5 ). The proteins Nsp1, Nsp5, Nsp7-10, Nsp14-16, ORF4, ORF7a, ORF7b and ORF10 mainly possessed synonymous substitutions and hence were mostly devoid of amino acid changes. The 57
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