Author: Li, Zhao-Hong; Li, Chien-Ming; Ling, Pin; Shen, Fang-Hsiu; Chen, Shih-Heng; Liu, Ching-Chuan; Yu, Chun-Keung; Chen, Shun-Hua
Title: Ribavirin Reduces Mortality in Enterovirus 71–Infected Mice by Decreasing Viral Replication Cord-id: femlz8z2 Document date: 2008_3_15
ID: femlz8z2
Snippet: Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC(50) of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the
Document: Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC(50) of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug
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