Author: Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; Marylyn M. Addo; Felix F. Loeffler
Title: Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series Document date: 2020_4_17
ID: icl1t9d6_21
Snippet: The dynamics of the immune response were analyzed by flow cytometry using PBMCs. The memory B-cell population (CD19+CD24+CD38-/low) increased, following infection after approximately 15 days post disease onset in both patients #1 and #2 (Fig. 1a, b) , and persisted in the severe case (#1) until d32. An expansion of plasmablasts (CD19+CD27+CD38+) in the blood circulation was detected in the mild case very early at day 3 post onset of symptoms (Fig.....
Document: The dynamics of the immune response were analyzed by flow cytometry using PBMCs. The memory B-cell population (CD19+CD24+CD38-/low) increased, following infection after approximately 15 days post disease onset in both patients #1 and #2 (Fig. 1a, b) , and persisted in the severe case (#1) until d32. An expansion of plasmablasts (CD19+CD27+CD38+) in the blood circulation was detected in the mild case very early at day 3 post onset of symptoms (Fig.1b) , before symptoms subsided. The severe case (#1)
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