Characteristics associated with household transmission of SARS-CoV-2 in Ontario, Canada: A cohort study

Paul, Lauren A; Daneman, Nick; Brown, Kevin A; Johnson, James; van Ingen, Trevor; Joh, Eugene; Wilson, Sarah E; Buchan, Sarah A

BACKGROUND: Within-household transmission of SARS-CoV-2 infection has been identified as one of the main sources of spread of COVID-19 after lockdown restrictions and self-isolation guidelines are implemented. Secondary attack rates among household contacts are estimated to be five to ten times higher than among non-household contacts, but it is unclear which individuals are more prone to transmit infection within their households. METHODS: Using address matching, a cohort was assembled of all laboratory-confirmed cases of COVID-19 residing in private households in Ontario, Canada. Descriptive analyses were performed to compare characteristics of cases in households that experienced secondary transmission versus those that did not. Logistic regression models were fit to determine index case characteristics and neighbourhood characteristics associated with transmission. RESULTS: Between January and July, 2020, there were 26,714 cases of COVID-19 residing in 21,226 households. Longer testing delays (≥5 days versus 0 days OR=3.02, 95% CI: 2.53 - 3.60) and male gender (OR=1.28, 95% CI: 1.18 - 1.38) were associated with greater odds of household secondary transmission, while being a healthcare worker (OR=0.56, 95% CI: 0.50 - 0.62) was associated with lower odds of transmission. Neighbourhoods with larger average family size and a higher proportion of households with multiple persons per room were also associated with greater odds of transmission. CONCLUSIONS: It is important for individuals to get tested for SARS-CoV-2 infection as soon as symptoms appear, and to isolate away from household contacts; this is particularly important in neighbourhoods with large family sizes and/or crowded households.