Author: Lugito, Nata Pratama Hardjo
Title: Is procalcitonin a part of human immunological response to SARS-CoV-2 infection or “just†a marker of bacterial coinfection? Cord-id: ru7eq7wm Document date: 2021_3_24
ID: ru7eq7wm
Snippet: Elevated PCT level in COVID-19 was associated with higher risk of severe disease and higher risk of overall mortality. An increased PCT level of PCT in COVID-19 patients especially in severe cases would be assumed as bacterial coinfection. Could PCT level increase in SARS-CoV-2 infection without bacterial coinfection? Several SARS-CoV-2 proteins activate STAT3-dependent transcriptional pathways particularly in monocytes, that could lead to increased PCT production. STAT3α isoform causes increas
Document: Elevated PCT level in COVID-19 was associated with higher risk of severe disease and higher risk of overall mortality. An increased PCT level of PCT in COVID-19 patients especially in severe cases would be assumed as bacterial coinfection. Could PCT level increase in SARS-CoV-2 infection without bacterial coinfection? Several SARS-CoV-2 proteins activate STAT3-dependent transcriptional pathways particularly in monocytes, that could lead to increased PCT production. STAT3α isoform causes increased ACE2 expression, resulting more SARS-CoV-2 infected cells and further production of PCT.
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