Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6

Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo

In the present study we investigated the effects of Aβ on diffusion MRI-derived NODDI and free water metrics in transgenic (Tg)CRND8 mice with early onset amyloidosis (Chishti et al., 2001) . To mimic the effects of chronic microgliosis and astrogliosis, we additionally used adenoassociated viral vector (AAV)-mediated brain-targeted expression of an inflammatory cytokine, Interleukin (IL)-6. IL6 expression results in widespread gliosis in the CNS in the absence of overt amyloidogenic or neurodegenerative pathology , and was thus All rights reserved. No reuse allowed without permission.