Selected article for: "cerebral peduncle hippocampus splenium and orientation dispersion"
Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6
  • Document date: 2019_2_27
    • ID: hyeygk64_59
    Snippet: To further characterize spatial configuration of neurite structures, we performed analysis for ODI ( Figure 6) . Lower values of ODI are observed in large WM regions (which appear darker tones), such as splenium, corpus callosum, fimbria, and higher values are observed in grey matter areas (in various light grey tones). Consistent with an increase in NDI (presumed increased density of axonal/dendritic processes), we observed that Aβ increased th.....
    Document: To further characterize spatial configuration of neurite structures, we performed analysis for ODI ( Figure 6) . Lower values of ODI are observed in large WM regions (which appear darker tones), such as splenium, corpus callosum, fimbria, and higher values are observed in grey matter areas (in various light grey tones). Consistent with an increase in NDI (presumed increased density of axonal/dendritic processes), we observed that Aβ increased their degree of orientation dispersion (geometric complexity or misorientation of axonal/dendritic processes). Thus, TgCRND8 had increased ODI in splenium, cerebral peduncle and hippocampus (splenium: main effect strain F1,43 = 33.8 p < 0.0001; cerebral peduncle: main effect strain F1,43 = 28.3 p < 0.0001; All rights reserved. No reuse allowed without permission.

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