Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_17
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.043273 doi: bioRxiv preprint in ORF8 and 8 in ORF9 ( Figure 3 ). Intriguingly, various important non-synonymous mutations were observed majorly in European and US continent while the mutations were mostly synonymous in Asian continent. These interesting observations can be used to infer the reason behind larger infectivity and pathogen.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.043273 doi: bioRxiv preprint in ORF8 and 8 in ORF9 ( Figure 3 ). Intriguingly, various important non-synonymous mutations were observed majorly in European and US continent while the mutations were mostly synonymous in Asian continent. These interesting observations can be used to infer the reason behind larger infectivity and pathogenicity in these regions (Table 5 ). Further two type of amino acid change viz., conservative and radial replacements were intensively studied with respect to previous reports stating the effect of such changes on the enzymatic activities.
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