Author: Kols, Nicola Isabelle; Aatola, Heli; Peltola, Ville; Xu, Man; Nora-Krukle, Zaiga; Hedman, Klaus; Zvirbliene, Aurelija; Toivola, Hanna; Vuorinen, Tytti; Koskinen, Juha M.; Bruning, Andrea H.L.; Christensen, Andreas; Söderlund-Venermo, Maria; Koskinen, Janne O.
Title: Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children Cord-id: awr2tbj0 Document date: 2019_9_4
ID: awr2tbj0
Snippet: BACKGROUND: Diagnosis of human bocavirus 1 (HBoV1) has been based on qualitative PCRs detecting HBoV1 DNA or detection of HBoV1 mRNA. OBJECTIVE: This study aims to assess whether a rapid and automated HBoV1 antigen test is suitable for diagnosis of acute HBoV1 infection. STUDY DESIGN: HBoV1 antigen detection has been compared with quantitative HBoV1 DNA PCR and HBoV1 mRNA RT-PCR. RESULTS AND CONCLUSION: We conclude that HBoV1 antigen detection has higher clinical specificity and positive predict
Document: BACKGROUND: Diagnosis of human bocavirus 1 (HBoV1) has been based on qualitative PCRs detecting HBoV1 DNA or detection of HBoV1 mRNA. OBJECTIVE: This study aims to assess whether a rapid and automated HBoV1 antigen test is suitable for diagnosis of acute HBoV1 infection. STUDY DESIGN: HBoV1 antigen detection has been compared with quantitative HBoV1 DNA PCR and HBoV1 mRNA RT-PCR. RESULTS AND CONCLUSION: We conclude that HBoV1 antigen detection has higher clinical specificity and positive predictive value than HBoV1 DNA qualitative PCRs, yet a lower sensitivity than HBoV1 mRNA detection. Additionally, HBoV1 antigen detection is beneficial in its rapidity and availability as a point-of-care test.
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