Author: Simonnet, Arthur; Chetboun, Mikael; Poissy, Julien; Raverdy, Violeta; Noulette, Jerome; Duhamel, Alain; Labreuche, Julien; Mathieu, Daniel; Pattou, Francois; Jourdain, Merce
Title: High prevalence of obesity in severe acute respiratory syndrome coronavirusâ€2 (SARSâ€CoVâ€2) requiring invasive mechanical ventilation Cord-id: s1kxxx1v Document date: 2020_4_9
ID: s1kxxx1v
Snippet: OBJECTIVE: The Covidâ€19 pandemic is rapidly spreading worldwide, notably in Europe and North America, where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirusâ€2 (SARSâ€CoVâ€2) has not been fully documented. METHODS: In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients
Document: OBJECTIVE: The Covidâ€19 pandemic is rapidly spreading worldwide, notably in Europe and North America, where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirusâ€2 (SARSâ€CoVâ€2) has not been fully documented. METHODS: In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARSâ€CoVâ€2, in a single French center. RESULTS: Obesity (BMI >30 kg/m2) and severe obesity (BMI >35 kg/m2) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories (p<0.01, Chi square test for trend), and it was greatest in patients with BMI >35 kg/m2 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex (p<0.05) and BMI (p<0.05), independent of age, diabetes, and hypertension. The odds ratio for IMV in patients with BMI >35 kg/m2 vs patients with BMI <25 kg/m2 was 7.36 (1.63â€33.14; p=0.02) CONCLUSION: The present study showed a high frequency of obesity among patients admitted in intensive care for SARSâ€CoVâ€2. Disease severity increased with BMI. Obesity is a risk factor for SARSâ€CoVâ€2 severity requiring increased attention to preventive measures in susceptible individuals.
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