Author: Pei-Hui Wang; Yun Cheng
Title: Increasing Host Cellular Receptor—Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus may Facilitate 2019-nCoV Infection Document date: 2020_2_27
ID: epy7774j_23
Snippet: Overexpression of TBK1, downstream of both TLR3 and RIG-I-like receptor signaling pathway, can strongly upregulate ACE2 mRNA level ( Figure 3) . TRIF, an adaptor protein of TLR3 pathway, also induce the expression of ACE2 in HEK293 cells (Figure 3 )......
Document: Overexpression of TBK1, downstream of both TLR3 and RIG-I-like receptor signaling pathway, can strongly upregulate ACE2 mRNA level ( Figure 3) . TRIF, an adaptor protein of TLR3 pathway, also induce the expression of ACE2 in HEK293 cells (Figure 3 ).
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