Thrombektomie in der klinischen Praxis – Was lernen wir aus Registerstudien?

Tiedt, Steffen; Dorn, Franziska

BACKGROUND: In 2015, randomized controlled trials (RCT) provided high-level evidence for the efficacy of endovascular thrombectomy in selected patients with acute ischemic stroke due to large vessel occlusion of the anterior circulation. Ever since, thrombectomy is strongly recommended for these patients and has been broadly implemented in clinical practice. OBJECTIVE: To determine whether registry studies depicting real-life data provide additional information beyond RCTs. MATERIAL AND METHODS: Literature review of RCTs and registry studies related to thrombectomy. RESULTS: Data from registry studies on thrombectomy are important to 1. evaluate whether RCT results can be directly transferred into clinical practice, 2. comparatively describe the efficacy of thrombectomy in patient groups underrepresented in RCTs, such as older patients, 3. compare device performances and assess technical developments, and 4. determine how treatment processes and outcomes change over time. CONCLUSION: Beyond RCTs, registry studies are imperative for the continuous analysis and improvement of treatment processes and outcomes as well as technical devices in daily clinical practice.