Selected article for: "IFN response and ISG expression"
Author: Scagnolari, Carolina; Pierangeli, Alessandra; Frasca, Federica; Bitossi, Camilla; Viscido, Agnese; Oliveto, Giuseppe; Scordio, Mirko; Mazzuti, Laura; Di Carlo, Daniele; Gentile, Massimo; Solimini, Angelo; Ceccarelli, Giancarlo; Pugliese, Francesco; Mastroianni, Claudio Maria; d’Ettorre, Gabriella; Turriziani, Ombretta; Antonelli, Guido
Title: Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)
  • Cord-id: g4k2iq9a
  • Document date: 2021_4_2
    • ID: g4k2iq9a
    Snippet: The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Hetero
    Document: The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.

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