Author: Gabriel A Brat; Griffin M Weber; Nils Gehlenborg; Paul Avillach; Nathan P Palmer; Luca Chiovato; James Cimino; Lemuel R Waitman; Gilbert S Omenn; Alberto Malovini; Jason H Moore; Brett K Beaulieu-Jones; Valentina Tibollo; Shawn N Murphy; Sehi L'Yi; Mark S Keller; Riccardo Bellazzi; David A Hanauer; Arnaud Serret-Larmande; Alba Gutierrez-Sacristan; John J Holmes; Douglas S Bell; Kenneth D Mandl; Robert W Follett; Jeffrey G Klann; Douglas A Murad; Luigia Scudeller; Mauro Bucalo; Katie Kirchoff; Jean Craig; Jihad Obeid; Vianney Jouhet; Romain Griffier; Sebastien Cossin; Bertrand Moal; Lav P Patel; Antonio Bellasi; Hans U Prokosch; Detlef Kraska; Piotr Sliz; Amelia LM Tan; Kee Yuan Ngiam; Alberto Zambelli; Danielle L Mowery; Emily Schiver; Batsal Devkota; Robert L Bradford; Mohamad Daniar; Christel Daniel; Vincent Benoit; Romain Bey; Nicolas Paris; Patricia Serre; Nina Orlova; Julien Dubiel; Martin Hilka; Anne Sophie Jannot; Stephane Breant; Judith Leblanc; Nicolas Griffon; Anita Burgun; Melodie Bernaux; Arnaud Sandrin; Elisa Salamanca; Thomas Ganslandt; Tobias Gradinger; Julien Champ; Martin Boeker; Patricia Martel; Alexandre Gramfort; Olivier Grisel; Damien Leprovost; Thomas Moreau; Gael Varoquaux; Jill Jen Vie; Demian Wassermann; Arthur Mensch; Charlotte Caucheteux; Christian Haverkamp; Guillaume Lemaitre; Christian Haverkamp; Tianxi Cai; Isaac S Kohane
Title: International Electronic Health Record-Derived COVID-19 Clinical Course Profile: The 4CE Consortium Document date: 2020_4_18
ID: 4y5279c5_6
Snippet: Multiple studies have reported significant abnormalities in several laboratory tests in patients with COVID-19. Studies have shown abnormalities in cardiac, hepatic, renal, immune, and coagulation physiology. Those laboratory results are associated with both disease presentation and severity. For this initial study, we selected a subset of laboratories that are commonly performed, as identified by the Regenstrief Institute responsible for the Log.....
Document: Multiple studies have reported significant abnormalities in several laboratory tests in patients with COVID-19. Studies have shown abnormalities in cardiac, hepatic, renal, immune, and coagulation physiology. Those laboratory results are associated with both disease presentation and severity. For this initial study, we selected a subset of laboratories that are commonly performed, as identified by the Regenstrief Institute responsible for the Logical Objects, Identifiers, Names and Codes (LOINC) standard, 18 and had been previously associated with worse outcomes in COVID-19 patients. Based on the meta-analysis of Lippi and Plebani, 19 we focused on 14 laboratory studies that are commonly performed: alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbili), albumin, cardiac troponin (high sensitivity), lactate dehydrogenase (LDH), Ddimer, white blood cell count (WBC), lymphocyte count, neutrophil count, procalcitonin, and prothrombin time. LOINC codes were identified for each laboratory study as well as the units and reference ranges.
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