Selected article for: "cell cycle and underlicensed cell cycle"
Author: Jacob Peter Matson; Amy M. House; Gavin D. Grant; Huaitong Wu; Joanna Perez; Jeanette Gowen Cook
Title: Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence
  • Document date: 2019_2_22
    • ID: dsbucda9_30
    Snippet: How frequently do cells experience this naturally-underlicensed cell cycle in vivo? Cell cycle re-entry from quiescence is common in tissues that naturally turn over cell populations (Sosa et al., 2014; Sagot and Laporte, 2019; Wells et al., 2013) . One might imagine however, that one risky cell cycle is a small contributor to overall genome instability. On the other hand, even in actively proliferating cultures, recent studies have detected popu.....
    Document: How frequently do cells experience this naturally-underlicensed cell cycle in vivo? Cell cycle re-entry from quiescence is common in tissues that naturally turn over cell populations (Sosa et al., 2014; Sagot and Laporte, 2019; Wells et al., 2013) . One might imagine however, that one risky cell cycle is a small contributor to overall genome instability. On the other hand, even in actively proliferating cultures, recent studies have detected populations of cells that appear to spontaneously and transiently exit to a quiescence-like state (Spencer et al., 2013; Overton et al., 2014; Arora et al., 2017; Barr et al., 2017) . Such transient cell cycle exit may be even more common in tissues compared than in cell culture conditions that have been optimized for maximal uninterrupted growth. Whether or not that transient quiescence also causes underlicensing is not yet known.

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