Peripheral Nervous System Manifestations Associated with COVID-19

Andalib, Sasan; Biller, José; Di Napoli, Mario; Moghimi, Narges; McCullough, Louise D; Rubinos, Clio A.; O’Hana Nobleza, Christa; Azarpazhooh, M. Reza; Catanese, Luciana; Elicer, Isabel; Jafari, Mostafa; Liberati, Fabrizio; Camejo, Claudia; Torbey, Michel; Divani, Afshin A.

PURPOSE OF REVIEW: The present review discusses the peripheral nervous system (PNS) manifestations associated with coronavirus disease 2019 (COVID-19). RECENT FINDINGS: Nerve pain and skeletal muscle injury, Guillain-Barré syndrome, cranial polyneuritis, neuromuscular junction disorders, neuro-ophthalmological disorders, neurosensory hearing loss, and dysautonomia have been reported as PNS manifestations in patients with COVID-19. SUMMARY: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. COVID-19 has shown syndromic complexity. Not only does SARS-CoV-2 affect the central nervous system but also it involves the PNS. The PNS involvement may be due to dysregulation of the immune system attributable to COVID-19. Here we review the broad spectrum of PNS involvement of COVID-19.