Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis

wenxiu Wu; zhifeng xu; yabin Jin; aizhen Pan

The atypical pneumonia case, caused by a novel coronavirus (2019-nCov), was first reported and confirmed in Wuhan, China in December 31, 2019 (Pneumonia of unknown cause-China,2020) [1] . Initially confined to Wuhan, the infection has spread elsewhere, sporadic cases exported from Wuhan were reported in many foreign countries.On January 30, the WHO Director-General declared that the 2019-nCov outbreak constitutes a Public Health Emergency of International Concern [2] . So far, the outbreak is still on-going, the number of reported cases of 2019-nCov infection continue to increase.Several relevant literatures estimated the transmissibility of 2019-nCoV, the mean estimate of R0 for the new coronavirus pneumonia (NCP) ranges from 1.4 to 3.58 [3, 4] . As of 18 February 2020, NCP has caused 73400 confirmed cases including 1870 deaths, 6242 suspected cases, and 12734 cured cases in mainland released by the National Health Commission of China. Now Japan has become the second most affected country with 519 confirmed cases, and followed by Singapore with 77 confirmed cases. Person-to-person transmission of NCP has been confirmed and with several ways of transmission, moreover the asymptomatic individual is identified as a potential source of infection. Fever and cough were reported as main clinical manifestations of NCP patients [5] . Based on the clinical observations and summary, the main diagnostic criteria [6] of 2019-nCov infections are : 1) Contact history of the epidemic area and related patients; 2) Nucleic acid is positive; 3) Fever, cough, shortness of breath and other clinical symptoms; 4) Laboratory examination showed that white blood cells were normal or decreased and lymphocytes decreased; 5) Lung lesions. Especially,the 1th and 2th standards were the most important for 2019-nCov infected confirm. However, in the diagnosis and treatment process, it was found that the above diagnostic criteria could not fully meet the needs of clinical prevention and control, and some atypical clinical manifestations appeared [5, 7, 8] , which brought great difficulties and challenges to the prevention and control of the epidemic.