Author: Pineton de Chambrun, Marc; Frere, Corinne; Miyara, Makoto; Amoura, Zahir; Martinâ€Toutain, Isabelle; Mathian, Alexis; Hekimian, Guillaume; Combes, Alain
Title: High Frequency of Antiphospholipid Antibodies in Criticallyâ€ill COVIDâ€19 Patients: a Link with Hypercoagulability? Cord-id: r14xwpm5 Document date: 2020_6_12
ID: r14xwpm5
Snippet: Coronavirus disease 2019 (COVIDâ€19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and Dâ€dimers levels that have been associated with poor prognosis and high rates of severe pulmonary embolism. A recent report suggested a role for antiphospholipid antibodies (aPLA) in the thrombotic manifestations associated with severe COVIDâ€19. As we also recently noticed unexplained lengthening of activated partial thro
Document: Coronavirus disease 2019 (COVIDâ€19) is associated with both severe systemic inflammation and a prothrombotic state, as reflected by significant increases in fibrinogen and Dâ€dimers levels that have been associated with poor prognosis and high rates of severe pulmonary embolism. A recent report suggested a role for antiphospholipid antibodies (aPLA) in the thrombotic manifestations associated with severe COVIDâ€19. As we also recently noticed unexplained lengthening of activated partial thromboplastin time (aPTT) in some critically ill COVIDâ€19 patients, we explored our patients for aPLA positivity.
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