Author: Sandra De Meyer; Denisa Bojkova; Jindrich Cinati; Ellen Van Damme; Christophe Buyck; Marnix Van Loock; Brian Woodfall; Sandra Ciesek
Title: Lack of Antiviral Activity of Darunavir against SARS-CoV-2 Document date: 2020_4_8
ID: 679qfp2s_32
Snippet: Several publications describe in silico docking experiments on the main coronavirus protease that specifically focus on or include DRV (17) (18) (19) (20) (21) . Although these studies suggest DRV as a candidate for further investigation, such promising docking results could not be reproduced in our in silico docking studies. Such discrepancies can often result from in silico docking, which is primarily a useful approach for identifying subsets o.....
Document: Several publications describe in silico docking experiments on the main coronavirus protease that specifically focus on or include DRV (17) (18) (19) (20) (21) . Although these studies suggest DRV as a candidate for further investigation, such promising docking results could not be reproduced in our in silico docking studies. Such discrepancies can often result from in silico docking, which is primarily a useful approach for identifying subsets of molecules for in vitro activity testing. No in vitro antiviral activity of DRV against SARS-CoV-2 was found in the experiments reported here. All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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