Author: Rosenke, Kyle; Hansen, Frederick; Schwarz, Benjamin; Feldmann, Friederike; Haddock, Elaine; Rosenke, Rebecca; Barbian, Kent; Meade-White, Kimberly; Okumura, Atsushi; Leventhal, Shanna; Hawman, David W.; Ricotta, Emily; Bosio, Catharine M.; Martens, Craig; Saturday, Greg; Feldmann, Heinz; Jarvis, Michael A.
Title: Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model Cord-id: vwh0roww Document date: 2021_4_16
ID: vwh0roww
Snippet: The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered
Document: The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans following high-risk exposure as well as for treatment of COVID-19 patients.
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