Selected article for: "bind ability and surface area"
Author: Cheng Wang; Shaobo Wang; Daixi Li; Xia Zhao; Songling Han; Tao Wang; Gaomei Zhao; Yin Chen; Fang Chen; Jianqi Zhao; Liting Wang; Wei Sun; Yi Huang; Yongping Su; Dongqing Wei; Jinghong Zhao; Junping Wang
Title: Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2
  • Document date: 2020_3_31
    • ID: bzq1xxqb_15
    Snippet: HD5 is constitutively expressed in vivo and acts as a peptide "ranger" regulating the intestinal microbiota 33 . The storage volume of HD5 in Paneth cells has been estimated 90-450 mg/cm 2 of ileal surface area 22 . In ileal fluid, HD5 content is quantified to 6-30 µg/mL 34 . Such a large dose of HD5 in intestine provides a possibility that it may capture ACE2 before 2019-nCoV lands to enterocytes, although the affinity of S1-ACE2 interaction is.....
    Document: HD5 is constitutively expressed in vivo and acts as a peptide "ranger" regulating the intestinal microbiota 33 . The storage volume of HD5 in Paneth cells has been estimated 90-450 mg/cm 2 of ileal surface area 22 . In ileal fluid, HD5 content is quantified to 6-30 µg/mL 34 . Such a large dose of HD5 in intestine provides a possibility that it may capture ACE2 before 2019-nCoV lands to enterocytes, although the affinity of S1-ACE2 interaction is higher than that of HD5 binding to ACE2. To evaluate the effect of HD5 coating on ACE2 interacting with S1, a blocking experiment was conducted by monitoring the bindings of S1 to ACE2 covered with different doses of HD5. As shown in Figure 1E , HD5 lowered the thickness of S1 binding to ACE2, indicative of a protective role of this peptide on viral adhesion. As HD5 is lectin-like peptide with multivalent binding ability 24 , we asked if HD5 could bind and block author/funder. All rights reserved. No reuse allowed without permission.

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