Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_24
Snippet: Importantly, alanine to valine substitution in non-structural protein, NS2A in Zika virus affects viral RNA synthesis and results in vivo viral attenuation (Marquez-Jurado et al., 2018) . This mutated virus also induce a comprehensive protection against lethal challenge proposed by the wild type Zika virus. Falling in similar lines alanine to valine substitutions in non-structural proteins (Nsp3, A1187V, Nsp4, A457V and Nsp6, A46V) could reduce v.....
Document: Importantly, alanine to valine substitution in non-structural protein, NS2A in Zika virus affects viral RNA synthesis and results in vivo viral attenuation (Marquez-Jurado et al., 2018) . This mutated virus also induce a comprehensive protection against lethal challenge proposed by the wild type Zika virus. Falling in similar lines alanine to valine substitutions in non-structural proteins (Nsp3, A1187V, Nsp4, A457V and Nsp6, A46V) could reduce viral lethality of hCoVs (Table 5 ). These mutations might pave way towards identification of less lethal strains and help to raise immunity to counteract the noxious strains. An isoleucine to valine mutation (Nsp2, I559V and Nsp3, I797V) and methionine to isoleucine (Nsp4, M33I)
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