Virus-receptor interactions of SARS-CoV-2 spike receptor-binding domain and human neuropilin-1 b1 domain

Alnomasy, Sultan F.

In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wahan, China and it causes disease which is known as COVID-19. This infection spreads everywhere in the global, and it leads to an enormous number of death among individuals. The mystery issue about SARS-CoV-2 that appears not have functions of a hemagglutinin and neuraminidase like other coronaviruses. Angiotensin-converting enzyme 2 (ACE2) is the main surface receptor for entering SARS-CoV-2 into the host cell. This entry process is mediated by binding SARS-CoV-2 spike receptor-binding domain (RBD) domain to ACE2. Recently, researchers discover a new receptor responsible for the SARS-CoV-2 entry which is neuropilin-1 (NRP1). So, this work provide afford a knowledge of how the interaction between SARS-CoV-2 spike RBD domain and NRP1 b1 domain is occurred. Understanding of the interaction would be very necessary for drug design.