Updated experience of a tertiary pandemic center on 533 pregnant women with COVID-19 infection: A prospective cohort study from Turkey.

Sahin, Dilek; Tanacan, Atakan; Erol, Seyit A; Anuk, Ali T; Yetiskin, Fatma D Y; Keskin, Huseyin L; Ozcan, Namik; Ozgu-Erdinc, A Seval; Eyi, Elif G Y; Yucel, Aykan; Tayman, Cuneyt; Unlu, Serpil; Dinc, Bedia; Sari, Eyup; Surel, Aziz A; Moraloglu, Ozlem T

OBJECTIVE To investigate the clinical course and impact of coronavirus disease 2019 (COVID-19) infection on pregnant women. METHODS A prospective cohort study was conducted on pregnant women with confirmed COVID-19 infection. Demographic features, clinical characteristics, and perinatal outcomes were prospectively evaluated. RESULTS Of the 533 cases, 161 (30.2%) had co-morbidities and 165 (30.9%) were asymptomatic. Cough (n=178, 33.4%) and myalgia (n=168, 31.5%) were the leading symptoms. In total, 261 patients (48.9%) received COVID-19 therapy, 509 (95.5%) had mild disease, 7 (1.3%) were admitted to the intensive care unit (ICU), and invasive mechanical ventilation was necessary in 2 (0.4%) patients. Maternal mortality was observed in 2 (0.4%) cases. Of the patients, 297 (55.7%) were hospitalized, 39 (7.3%) had suspicious radiologic imaging findings, 66 (12.4) had pregnancy complications (preterm delivery [n=22, 4.1%] and miscarriage [n=12, 2.2%] were the most common pregnancy complications), 131 births occurred, and the cesarean section rate was 66.4%. All neonates were negative for COVID-19. The rate of admission to the neonatal ICU was 9.9%. One specimen of breast milk was positive for the infection. CONCLUSION The course of COVID-19 was mild in the majority of cases. However, increased rates of pregnancy complications and cesarean delivery were observed.