Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients?

Popescu, Cristian-Marian; Ursache, Aurora Livia; Feketea, Gavriela; Bocsan, Corina; Jimbu, Laura; Mesaros, Oana; Edwards, Michael; Wang, Hongwei; Berceanu, Iulia; Neaga, Alexandra; Zdrenghea, Mihnea

Despite a plethora of studies demonstrating significant morbidity and mortality due to community-acquired respiratory viral (CRV) infections in intensively treated hematology patients, and despite the availability of evidence-based guidelines for the diagnosis and management of respiratory viral infections in this setting, there is no uniform inclusion of respiratory viral infection management in the clinical hematology routine. Nevertheless, timely diagnosis and systematic management of CRV infections in intensively treated hematology patients has a demonstrated potential to significantly improve outcome. We have briefly summarized the recently published data on CRV infection epidemiology, as well as guidelines on the diagnosis and management of CRV infections in patients intensively treated for hematological malignancies. We have also assessed available treatment options, as well as mentioned novel agents currently in development.