Author: Mitra-Kaushik, Shibani; Mehta-Damani, Anita; Stewart, Jennifer J.; Green, Cherie; Litwin, Virginia; Gonneau, Christèle
Title: The Evolution of Single-Cell Analysis and Utility in Drug Development Cord-id: fqe8mb19 Document date: 2021_8_13
ID: fqe8mb19
Snippet: This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vac
Document: This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies. Graphical abstract [Image: see text]
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