Author: Yi Han; Haidong Zhang; Sucheng Mu; Wei Wei; Chaoyuan Jin; Yuan Xue; Chaoyang Tong; Yunfei Zha; Zhenju Song; Guorong Gu
Title: Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients Document date: 2020_3_27
ID: 54o2p36a_9
Snippet: We used PSI and the Curb-65 score to assess the disease severity of pneumonia in COVID-19 patients. The average PSI score was 86 in severe cases versus 61 in nonsevere cases (Table 1 , P = 0.003), with Curb-65 scores of 1.13 versus 0.48 (Table 1 , P = 0.001). We also evaluated the extent of inflammation on chest CT using a semiquantitative scoring system (Supplement Table 1 ); the median score was 5.0 in severe cases while only 2.0 in non-severe .....
Document: We used PSI and the Curb-65 score to assess the disease severity of pneumonia in COVID-19 patients. The average PSI score was 86 in severe cases versus 61 in nonsevere cases (Table 1 , P = 0.003), with Curb-65 scores of 1.13 versus 0.48 (Table 1 , P = 0.001). We also evaluated the extent of inflammation on chest CT using a semiquantitative scoring system (Supplement Table 1 ); the median score was 5.0 in severe cases while only 2.0 in non-severe cases ( Table 1 , P < 0.001). Six indicators above were futher performed Pearson correlation ananalysis with PSI score and CT score to determine the potential biomarkers for the lung injury. As a result, the serum LDH level still showed the highest R value with CT score (R = 0.8372, P < 0.001) and the second highest R value with PSI score (R = 0.465, P < 0.001) in all the indicators (Figure2. F&L). Nevertheless, the serum cTnI level showed no correlation with PSI score (R = 0.203, P = 0.198) nor CT score (R = 0.232, P = 0.167). What's more, the serum AST level showed no correlation with PSI score (R = 0.211, P = 0.165) and the serum BNP level showed no correlation CT score (R = 0.301, P = 0.837). Lymphocyte counts were neagtively associated with PSI score (R = -0.434, P = 0.003) and CT score (R = -0.602, P < 0.001), while serum CRP showed positvie correlation with the two scores. (Figure 2)
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