Author: Shi, Jinyun; Guo, Jia; Li, Zhidong; Xu, Baohui; Miyata, Masaaki
Title: Importance of NLRP3 Inflammasome in Abdominal Aortic Aneurysms Cord-id: dush0ae1 Document date: 2021_5_1
ID: dush0ae1
Snippet: Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease, which particularly affects older people. Nucleotide-binding oligomerization domain-like receptor family protein 3 (NLRP3) inflammasome is a multi-protein complex and mediates inflammatory responses by activating caspase 1 for processing premature interleukin (IL)-1β and IL-18. In this review, we first summarize the principle of NLRP3 inflammasome activation and the functionally distinct classes of small molec
Document: Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease, which particularly affects older people. Nucleotide-binding oligomerization domain-like receptor family protein 3 (NLRP3) inflammasome is a multi-protein complex and mediates inflammatory responses by activating caspase 1 for processing premature interleukin (IL)-1β and IL-18. In this review, we first summarize the principle of NLRP3 inflammasome activation and the functionally distinct classes of small molecule NLRP3 inflammasome inhibitors. Next, we provide a comprehensive literature review on the expression of NLRP3 inflammasome effector mediators (IL-1β and IL-18) and components (caspase 1, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and NLRP3) in clinical and experimental AAAs. Finally, we discuss the influence of genetic deficiency or pharmacological inhibition of individual effector mediators and components of NLRP3 inflammasome on experimental AAAs. Accumulating clinical and experimental evidence suggests that NLRP3 inflammasome may be a promise therapeutic target for developing pharmacological strategies for clinical AAA management.
Search related documents:
Co phrase search for related documents- aaa aortic aneurysm and abdominal aorta: 1, 2
- aaa aortic aneurysm and abdominal aortic aneurysm: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- aaa disease and abdominal aaa aortic aneurysm: 1, 2, 3, 4, 5, 6
- aaa disease and abdominal aortic aneurysm: 1, 2, 3, 4, 5, 6
- aaa formation and abdominal aaa aortic aneurysm: 1, 2
- aaa formation and abdominal aortic aneurysm: 1, 2
- aaa incidence and abdominal aaa aortic aneurysm: 1, 2
- aaa incidence and abdominal aortic aneurysm: 1, 2
- aaa inhibition and abdominal aaa aortic aneurysm: 1
- aaa inhibition and abdominal aortic aneurysm: 1
- aaa modeling and abdominal aaa aortic aneurysm: 1
- aaa modeling and abdominal aortic aneurysm: 1
- aaa pathogenesis and abdominal aaa aortic aneurysm: 1, 2, 3
- aaa pathogenesis and abdominal aortic aneurysm: 1, 2, 3
- aaa patient and abdominal aaa aortic aneurysm: 1, 2, 3, 4
- aaa patient and abdominal aortic aneurysm: 1, 2, 3, 4
- aaa prevalence and abdominal aaa aortic aneurysm: 1, 2
- aaa prevalence and abdominal aortic aneurysm: 1, 2
Co phrase search for related documents, hyperlinks ordered by date