Author: William E. Diehl; Mehmet H. Guney; Pyae Phyo Kyawe; Judith M. White; Massimo Pizzato; Jeremy Luban
Title: Influence of different glycoproteins and of the virion core on SERINC5 antiviral activity Document date: 2019_9_24
ID: 9dybtdi2_3
Snippet: HIV-1 Nef is important for maximal HIV-1 replication in vivo and for progression to AIDS (1) (2) (3) . Nef is a multifunctional accessory protein that downregulates CD4, MHC, and TCR from the cell surface (4) (5) (6) (7) (8) . Nef also enhances HIV-1 infectivity in single-round infection experiments (9) (10) (11) (12) (13) (14) (15) (16) by overcoming the antiviral effects of SERINC5 and SERINC3 (17, 18) , though, of the two, SERINC5 is the more .....
Document: HIV-1 Nef is important for maximal HIV-1 replication in vivo and for progression to AIDS (1) (2) (3) . Nef is a multifunctional accessory protein that downregulates CD4, MHC, and TCR from the cell surface (4) (5) (6) (7) (8) . Nef also enhances HIV-1 infectivity in single-round infection experiments (9) (10) (11) (12) (13) (14) (15) (16) by overcoming the antiviral effects of SERINC5 and SERINC3 (17, 18) , though, of the two, SERINC5 is the more potent restriction factor. SERINC5 is incorporated into budding virions where it inhibits subsequent fusion of the virion membrane with target cell membranes. Nef counteracts SERINC5 by removing it from the cell surface so that it is not incorporated into nascent virions (17) (18) (19) (20) .
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