Systematic screening for a proximal DVT in COVID-19 hospitalized patients: results of a comparative study

Fares, Yara; Eyoum, Yeyinou Calliste Sinzogan; Billoir, Paul; Bogaert, Aymeric; Armengol, Guillaume; Alexandre, Kevin; Lammens, Justine; Grall, Maximillien; Levesque, Hervé; Benhamou, Ygal; Miranda, Sebastien

INTRODUCTION: The COVID-19 pandemic is associated with a high incidence of venous thromboembolism questioning the utility of a systematic screening for deep venous thrombosis (DVT) in hospitalised patients. METHODS: In this prospective bicentric controlled study, 4-point ultrasound using a pocket device was used to screen for DVT, in patients with SARS-CoV-2 infection and controls admitted for acute medical illness not related to COVID-19 hospitalised in general ward, in order to assess the utility of a routine screening and to estimate the prevalence of VTE among those patients. RESULTS: Between April and May 2020, 135 patients were screened, 69 in the COVID+ group and 66 in the control one. There was no significant difference in the rate of proximal DVT between the two groups (2.2% vs 1.5%; p=0.52), despite the high rate of PE diagnosed among COVID-19 infected patients (10.1% vs 1.5%, p=0.063). No isolated DVT was detected, 37.5% of PE was associated with DVT. Mortality (7.2% vs 1.5%) was not different (p=0.21) between COVID-19 patients and controls. CONCLUSION: The systematic screening for proximal DVT was not found to be relevant among COVID-19 patients hospitalized in general ward despite the increase of VTE among this population. Further studies are needed to confirm the hypothesis of a local pulmonary thrombosis which may lead to new therapeutic targets.