Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_111
Snippet: We did not find a positive association between pre-existing immunity to non-recent strains (i.e. nAUC or nW 40 ) and seroconversion to recent strain when titer to strain i and titer to strain i-1 (which is highly correlated with titer to strain i) were not adjusted (Model 3 in table S6), which is probably due to the positive correlation between pre-existing immunity to non-recent strains and titer to strain i (table S10). Therefore, we hypothesiz.....
Document: We did not find a positive association between pre-existing immunity to non-recent strains (i.e. nAUC or nW 40 ) and seroconversion to recent strain when titer to strain i and titer to strain i-1 (which is highly correlated with titer to strain i) were not adjusted (Model 3 in table S6), which is probably due to the positive correlation between pre-existing immunity to non-recent strains and titer to strain i (table S10). Therefore, we hypothesize that pre-existing immunity to nonrecent strains imposes both indirect effects mediated by titer to strain i and a direct effect on seroconversion to strain i. In order to further separate the direct effect of immunity of non-recent . CC-BY-NC 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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