Author: Kenneth Lyon; Luis U. Aguilera; Tatsuya Morisaki; Brian Munsky; Timothy J. Stasevich
Title: Live-cell single RNA imaging reveals bursts of translational frameshifting Document date: 2018_11_24
ID: 4fm1skgh_10
Snippet: As a first step to quantify frameshifting dynamics at the single-molecule level, we tracked thousands of individual RNA approximately two to ten hours post transfection with and without the FSS sequence present (±FSS; Fig. 2A -C). In the +FSS cells, we found 92 ± 1.3% of translation sites were translating the canonical 0 frame alone, while 6.2 ± 1.1% were translating both the 0 and -1 frames. Only rarely did we observe translation All rights r.....
Document: As a first step to quantify frameshifting dynamics at the single-molecule level, we tracked thousands of individual RNA approximately two to ten hours post transfection with and without the FSS sequence present (±FSS; Fig. 2A -C). In the +FSS cells, we found 92 ± 1.3% of translation sites were translating the canonical 0 frame alone, while 6.2 ± 1.1% were translating both the 0 and -1 frames. Only rarely did we observe translation All rights reserved. No reuse allowed without permission.
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