Selected article for: "ICU admission and worldwide concern"
Author: Russick, Jules; Foy, Pierre-Emmanuel; Josseaume, Nathalie; Meylan, Maxime; Hamouda, Nadine Ben; Kirilovsky, Amos; Sissy, Carine El; Tartour, Eric; Smadja, David M.; Karras, Alexandre; Hulot, Jean-Sébastien; Livrozet, Marine; Fayol, Antoine; Arlet, Jean-Benoit; Diehl, Jean-Luc; Dragon-Durey, Marie-Agnès; Pagès, Franck; Cremer, Isabelle
Title: Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine
  • Cord-id: g3o55scl
  • Document date: 2021_7_12
    • ID: g3o55scl
    Snippet: SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome, requiring intensive care units (ICU) admission. The optimal management of hospitalized patients has become a worldwide concern and identification of immune biomarkers predictive of the clinical outcome for hospitalized patients remains a major challenge. Immunophenotyping and transcriptomic analysis of hospitalized COVID-19 patients at admissio
    Document: SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome, requiring intensive care units (ICU) admission. The optimal management of hospitalized patients has become a worldwide concern and identification of immune biomarkers predictive of the clinical outcome for hospitalized patients remains a major challenge. Immunophenotyping and transcriptomic analysis of hospitalized COVID-19 patients at admission allow identifying the two categories of patients. Inflammation, high neutrophil activation, dysfunctional monocytic response and a strongly impaired adaptive immune response was observed in patients who will experience the more severe form of the disease. This observation was validated in an independent cohort of patients. Using in silico analysis on drug signature database, we identify differential therapeutics that specifically correspond to each group of patients. From this signature, we propose a score—the SARS-Score—composed of easily quantifiable biomarkers, to classify hospitalized patients upon arrival to adapt treatment according to their immune profile.

    Search related documents:
    Co phrase search for related documents
    • activation status and adaptive immune response: 1, 2
    • activation status and adaptive immunity: 1, 2, 3, 4
    • activation status and adaptive immunity innate: 1, 2
    • acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute ards respiratory distress syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
    • acute ards respiratory distress syndrome and adaptive immunity innate: 1, 2, 3, 4, 5
    • acute ards respiratory distress syndrome and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and admission group: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acute injury and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8
    • acute injury and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute injury and adaptive immunity innate: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute injury and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute injury and admission group: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acute patient and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute patient report and admission day: 1, 2
    • adaptive immunity and admission group: 1
    • adaptive immunity innate and admission group: 1