Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Document date: 2020_3_12
ID: j5bepvvw_17
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.09.983247 doi: bioRxiv preprint Comparison of increasing PEG-based arm lengths in EK1C4 shows that inhibitors 250 potency slightly decreased in the cell-cell fusion assay (Fig. 4e) . The data suggest that 251 "GSGSG-PEG4" linker was optimal to bridge both parts of the conjugates. Similarly, 252 EK1C4 showed the most potent inhibitory acti.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.09.983247 doi: bioRxiv preprint Comparison of increasing PEG-based arm lengths in EK1C4 shows that inhibitors 250 potency slightly decreased in the cell-cell fusion assay (Fig. 4e) . The data suggest that 251 "GSGSG-PEG4" linker was optimal to bridge both parts of the conjugates. Similarly, 252 EK1C4 showed the most potent inhibitory activity against SARS-CoV-2 PsV 253 infection, with IC 50 value of 15.8 nM, providing 149-fold stronger anti-SARS-CoV-2 254 activity than that of EK1 (IC 50 =2,375 nM) (Fig. 4f) .
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