Author: Michael T. Parker; Smita Gopinath; Corey E. Perez; Melissa M. Linehan; Jason M. Crawford; Akiko Iwasaki; Brett D. Lindenbach
Title: Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus Infection Document date: 2018_10_3
ID: j1gkl43g_1
Snippet: Introduction mechanisms and may restrict RNA virus replication independent of IRF3 activation 89 (20) . 90 cGAS is a nucleic acid-binding protein specific for dsDNA and DNA:RNA hybrids 91 that also has nucleotidyl transferase activity (21) (22) (23) (24) . DNA binding induces structural 92 changes to form the cGAS active site, which synthesizes a non-canonical 5´-2'-and 93 5´-3'-linked cyclic dinucleotide known as cyclic guanosine monophosphate.....
Document: Introduction mechanisms and may restrict RNA virus replication independent of IRF3 activation 89 (20) . 90 cGAS is a nucleic acid-binding protein specific for dsDNA and DNA:RNA hybrids 91 that also has nucleotidyl transferase activity (21) (22) (23) (24) . DNA binding induces structural 92 changes to form the cGAS active site, which synthesizes a non-canonical 5´-2'-and 93 5´-3'-linked cyclic dinucleotide known as cyclic guanosine monophosphate-94 adenosine monophosphate (cGAMP) (25-28). cGAMP is a diffusible secondary 95 messenger that specifically binds to STING with high affinity (K D ~4 nM), thereby 96 inducing a downstream innate immune response (29) (30) (31) (32) . 97
Search related documents:
Co phrase search for related documents- cyclic dinucleotide and dna bind: 1
- cyclic dinucleotide and immune response: 1, 2, 3
- cyclic dinucleotide and virus replication: 1
- cyclic guanosine cGAMP adenosine monophosphate and immune response: 1
- dna bind and high affinity: 1, 2, 3, 4, 5, 6, 7, 8
- dna bind and immune response: 1
- dna bind and rna hybrid: 1, 2
- dna bind and virus replication: 1, 2
- downstream innate immune response and immune response: 1, 2, 3, 4, 5
- downstream innate immune response and virus replication: 1
- high affinity and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49
- high affinity and introduction mechanism: 1
- high affinity and rna hybrid: 1
- high affinity and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- immune response and introduction mechanism: 1
- immune response and transferase activity: 1
- immune response and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77
- introduction mechanism and virus replication: 1
- rna hybrid and virus replication: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date