Selected article for: "active site and virus replication"
Author: Michael T. Parker; Smita Gopinath; Corey E. Perez; Melissa M. Linehan; Jason M. Crawford; Akiko Iwasaki; Brett D. Lindenbach
Title: Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus Infection
  • Document date: 2018_10_3
    • ID: j1gkl43g_1
    Snippet: Introduction mechanisms and may restrict RNA virus replication independent of IRF3 activation 89 (20) . 90 cGAS is a nucleic acid-binding protein specific for dsDNA and DNA:RNA hybrids 91 that also has nucleotidyl transferase activity (21) (22) (23) (24) . DNA binding induces structural 92 changes to form the cGAS active site, which synthesizes a non-canonical 5´-2'-and 93 5´-3'-linked cyclic dinucleotide known as cyclic guanosine monophosphate.....
    Document: Introduction mechanisms and may restrict RNA virus replication independent of IRF3 activation 89 (20) . 90 cGAS is a nucleic acid-binding protein specific for dsDNA and DNA:RNA hybrids 91 that also has nucleotidyl transferase activity (21) (22) (23) (24) . DNA binding induces structural 92 changes to form the cGAS active site, which synthesizes a non-canonical 5´-2'-and 93 5´-3'-linked cyclic dinucleotide known as cyclic guanosine monophosphate-94 adenosine monophosphate (cGAMP) (25-28). cGAMP is a diffusible secondary 95 messenger that specifically binds to STING with high affinity (K D ~4 nM), thereby 96 inducing a downstream innate immune response (29) (30) (31) (32) . 97

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