Selected article for: "entry protein and gene expression"
Author: AJ Venkatakrishnan; Arjun Puranik; Akash Anand; David Zemmour; Xiang Yao; Xiaoying Wu; Ramakrishna Chilaka; Dariusz K Murakowski; Kristopher Standish; Bharathwaj Raghunathan; Tyler Wagner; Enrique Garcia-Rivera; Hugo Solomon; Abhinav Garg; Rakesh Barve; Anuli Anyanwu-Ofili; Najat Khan; Venky Soundararajan
Title: Knowledge synthesis from 100 million biomedical documents augments the deep expression profiling of coronavirus receptors
  • Document date: 2020_3_29
    • ID: j7t9nebs_20
    Snippet: This analysis highlights a robust expression of ACE2 in tongue keratinocytes that has not been strongly documented in the literature, as evidenced by the weak local context score between ACE2 and keratinocytes ( Figure 4B ). In fact, we found no previous reports of ACE2 expression in keratinocytes and only one recent report suggesting ACE2 expression in the human tongue based on a combination of bulk RNA-seq and a scRNA-seq dataset which has not .....
    Document: This analysis highlights a robust expression of ACE2 in tongue keratinocytes that has not been strongly documented in the literature, as evidenced by the weak local context score between ACE2 and keratinocytes ( Figure 4B ). In fact, we found no previous reports of ACE2 expression in keratinocytes and only one recent report suggesting ACE2 expression in the human tongue based on a combination of bulk RNA-seq and a scRNA-seq dataset which has not been made publicly accessible 43 . We propose that a subset of ACE2 + tongue keratinocytes may serve as a novel site of SARS-CoV-2 entry and highlight the need to generate additional gene and protein expression data from human tongue samples to further evaluate this hypothesis. Emerging reports of loss of taste (dysgeusia) in otherwise non-symptomatic COVID-19 patients may warrant further study of the tongue in this pathology 44 .

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