Author: Ian M. Silverman; Sager J. Gosai; Nicholas Vrettos; Shawn W. Foley; Nathan D. Berkowitz; Zissimos Mourelatos; Brian D. Gregory
Title: Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo Document date: 2018_4_6
ID: 1pbshnw9_79
Snippet: Surprisingly, AGO-bound stem-loop containing mRNAs were not impacted following siRNA-mediated knockdown of components of the microprocessor complex (Fig. 5I) . Our results strongly support the presence of AGO-associated stem-loops from mRNAs, however their biogenesis pathway remains undetermined. Furthermore, we found limited evidence for further processing into mature miRNA-like smRNAs, which may be cell-type or contextdependent and thus should .....
Document: Surprisingly, AGO-bound stem-loop containing mRNAs were not impacted following siRNA-mediated knockdown of components of the microprocessor complex (Fig. 5I) . Our results strongly support the presence of AGO-associated stem-loops from mRNAs, however their biogenesis pathway remains undetermined. Furthermore, we found limited evidence for further processing into mature miRNA-like smRNAs, which may be cell-type or contextdependent and thus should be the target of future investigations.
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