Author: Georgi Momekov; Denitsa Momekova
Title: Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view Document date: 2020_4_17
ID: 3hgmuyn4_16
Snippet: It has to be emphasized that general public communication of drugs as potential COVID-19 therapeutics, based solely on in vitro data, is neither scientifically nor ethically appropriate. Ivermectin has been previously shown to exert antiviral activity in vitro against Dengue fever virus (DENV) 33 , influenza virus 34 , West Nile Virus 35 , Venezuelan equine encephalitis virus 36 , and heralded as possible antiviral drug, but so far there has not .....
Document: It has to be emphasized that general public communication of drugs as potential COVID-19 therapeutics, based solely on in vitro data, is neither scientifically nor ethically appropriate. Ivermectin has been previously shown to exert antiviral activity in vitro against Dengue fever virus (DENV) 33 , influenza virus 34 , West Nile Virus 35 , Venezuelan equine encephalitis virus 36 , and heralded as possible antiviral drug, but so far there has not been any clinical translation of these data. Noteworthy a clinical trial for the treatment of Dengue fever in Thailand failed to show clinical benefits 11 . In light to the aforementioned pharmacokinetic considerations this is not surprising given the published inhibitory concentrations against DENV1-4 ranged 1.66 -2.32 µM 33 .
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