Author: Poon, Terence C.W.; Pang, Ronald T.K.; Chan, K.C. Allen; Lee, Nelson L.S.; Chiu, Rossa W.K.; Tong, Yuâ€Kwan; Chim, Stephen S.C.; Ngai, Sai M.; Sung, Joseph J.Y.; Lo, Y.M. Dennis
Title: Proteomic analysis reveals platelet factor 4 and betaâ€thromboglobulin as prognostic markers in severe acute respiratory syndrome Cord-id: vnjuubt4 Document date: 2012_6_28
ID: vnjuubt4
Snippet: Previously, we reported that proteomic fingerprints were present in sera of patients with severe acute respiratory syndrome (SARS), and could separate patients into subgroups with different prognoses. In the present study, we examined the prognostic values of the SARSâ€associated proteomic features by biostatistical analysis, and deciphered the identities of those with prognostic values. Data of 20 SARSâ€associated serum proteomic features and ten serological variables from 38 SARS adult patie
Document: Previously, we reported that proteomic fingerprints were present in sera of patients with severe acute respiratory syndrome (SARS), and could separate patients into subgroups with different prognoses. In the present study, we examined the prognostic values of the SARSâ€associated proteomic features by biostatistical analysis, and deciphered the identities of those with prognostic values. Data of 20 SARSâ€associated serum proteomic features and ten serological variables from 38 SARS adult patients before treatment were subjected to multivariate logistic regression. Proteomic features of m/z 6634, m/z 7769, m/z 8635, and m/z 8865 were identified as independent prognostic markers. After purification by cationâ€exchange chromatography and gel electrophoresis, proteomic features of m/z 7769 and m/z 8865 were found to be platelet factor 4 (PF4) and betaâ€thromboglobulin (betaâ€TG) by tandem mass spectrometry, respectively. The associations of decreased serum PF4 and increased serum betaâ€TG levels with poor prognosis were confirmed by Western blot. Previous studies suggest that PF4 and betaâ€TG are involved in the pathogenesis of acute respiratory distress syndrome (ARDS) in a negative and positive way, respectively. Our results suggest that PF4 and betaâ€TG may also play similar roles in the development of ARDS in SARS patients.
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