Selected article for: "median value and patient number"
Author: Tobias Herold; Vindi Jurinovic; Chiara Arnreich; Johannes C Hellmuth; Michael Bergwelt-Baildon; Matthias Klein; Tobias Weinberger
Title: Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients
  • Document date: 2020_4_4
    • ID: 8udyoutb_7
    Snippet: In addition to IL-6 values at first assessment, follow-up data on IL-6 were also available (median number of values per patient: 6, range 1-10). These data were used to assess the maximal IL-6 level for each patient during disease (for patients requiring ventilation, only values before intubation were used). These values predicted respiratory failure with high accuracy (figure 1B/C, p=1.7·10 -8 , AUC=0.98). The statistically optimal cutoff for I.....
    Document: In addition to IL-6 values at first assessment, follow-up data on IL-6 were also available (median number of values per patient: 6, range 1-10). These data were used to assess the maximal IL-6 level for each patient during disease (for patients requiring ventilation, only values before intubation were used). These values predicted respiratory failure with high accuracy (figure 1B/C, p=1.7·10 -8 , AUC=0.98). The statistically optimal cutoff for IL-6 was 80pg/ml, identifying all but one patient with respiratory failure correctly, and misclassifying only one patient that still does not require intubation. The risk of respiratory failure for patients with IL-6 levels of ≥80pg/ml was 92% and thus 22 times higher compared to patients with lower IL-6 levels. After reaching an IL-6 value of 80pg/ml, the median time to mechanical ventilation was 1.5 days (range 0-4 days).

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