Selected article for: "possible target and secondary structure"
Author: Chunxi Zeng; Xucheng Hou; Jingyue Yan; Chengxiang Zhang; Wenqing Li; Weiyu Zhao; Shi Du; Yizhou Dong
Title: Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo
  • Document date: 2020_4_5
    • ID: aju2nr9x_12
    Snippet: MicroRNAs were previously considered to mainly target the 3' UTR of mRNA for gene regulations 28 . However, recent data showed that miRNAs also interfered with ribosomal scanning by binding to target sites within 5' UTR 29 . Hence, we examined possible miRNA target sites within NCA-7 and NCA-8 using the prediction tool available at miRDB. The prediction exhibited that both NCA-7 and NCA-8 contained miRNA target sites (Supplementary Table 2 ). The.....
    Document: MicroRNAs were previously considered to mainly target the 3' UTR of mRNA for gene regulations 28 . However, recent data showed that miRNAs also interfered with ribosomal scanning by binding to target sites within 5' UTR 29 . Hence, we examined possible miRNA target sites within NCA-7 and NCA-8 using the prediction tool available at miRDB. The prediction exhibited that both NCA-7 and NCA-8 contained miRNA target sites (Supplementary Table 2 ). Then, we adjusted the order of the nucleotides of NCA-7 and NCA-8 and created NCA-7d and NCA-8d, which maintain their nucleotide compositions with minimal secondary structure. Interestingly, NCA-7d showed a slightly increased author/funder. All rights reserved. No reuse allowed without permission.

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