Selected article for: "ER stress and oxidative stress"
Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress
  • Document date: 2019_6_20
    • ID: dt0b7jnu_4
    Snippet: In the present study, the mechanisms by which PPARA prevents inflammation during periods of metabolic stress were investigated. RNA-seq was carried out on livers from mice treated with the PPARA agonist WY-14643, and large numbers of differentially expressed protein coding genes and lncRNA genes were identified. These studies led to discovery of a regulatory axis between thioredoxin-interacting protein (TXNIP) and an antisense lncRNA, Gm15441. TX.....
    Document: In the present study, the mechanisms by which PPARA prevents inflammation during periods of metabolic stress were investigated. RNA-seq was carried out on livers from mice treated with the PPARA agonist WY-14643, and large numbers of differentially expressed protein coding genes and lncRNA genes were identified. These studies led to discovery of a regulatory axis between thioredoxin-interacting protein (TXNIP) and an antisense lncRNA, Gm15441. TXNIP acts as a critical relay linking oxidative and endoplasmic reticulum (ER) stress to inflammation through NLRP3 inflammasome activation (Anthony and Wek, 2012; Oslowski et al., 2012) .

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