Selected article for: "inflammasome activation and metabolic stress"
Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress
  • Document date: 2019_6_20
    • ID: dt0b7jnu_4
    Snippet: In the present study, the mechanisms by which PPARA prevents inflammation during periods of metabolic stress were investigated. RNA-seq was carried out on livers from mice treated with the PPARA agonist WY-14643, and large numbers of differentially expressed protein coding genes and lncRNA genes were identified. These studies led to discovery of a regulatory axis between thioredoxin-interacting protein (TXNIP) and an antisense lncRNA, Gm15441. TX.....
    Document: In the present study, the mechanisms by which PPARA prevents inflammation during periods of metabolic stress were investigated. RNA-seq was carried out on livers from mice treated with the PPARA agonist WY-14643, and large numbers of differentially expressed protein coding genes and lncRNA genes were identified. These studies led to discovery of a regulatory axis between thioredoxin-interacting protein (TXNIP) and an antisense lncRNA, Gm15441. TXNIP acts as a critical relay linking oxidative and endoplasmic reticulum (ER) stress to inflammation through NLRP3 inflammasome activation (Anthony and Wek, 2012; Oslowski et al., 2012) .

    Search related documents:
    Co phrase search for related documents
    • code gene and protein code gene: 1
    • differentially express and present study: 1
    • endoplasmic oxidative reticulum and inflammation stress: 1, 2, 3
    • endoplasmic oxidative reticulum and large number: 1
    • endoplasmic oxidative reticulum and metabolic stress: 1
    • ER inflammation stress and inflammasome activation: 1, 2
    • ER inflammation stress and inflammation stress: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • inflammasome activation and lncrna gene: 1
    • inflammasome activation and metabolic stress: 1, 2, 3, 4, 5, 6, 7
    • inflammasome activation and PPARA agonist: 1
    • inflammasome activation and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • inflammasome activation and regulatory axis: 1, 2
    • inflammasome activation and RNA seq: 1
    • inflammation prevent and large number: 1