Key to successful treatment of COVID-19: accurate identification of severe risks and early intervention of disease progression

meizhu chen; changli tu; Cuiyan Tan; Xiaobin Zheng; xiaohua wang; jian wu; Yiying Huang; zhenguo wang; yan yan; zhonghe li; hong shan; Jing Liu; jin huang

For the above indicators with significant differences in COVID-19, we are more concerned about their changes in the course of disease, especially for the prediction of severe disease. Lymphocyte count, CRP, D-dimer, BNP, albumin, and potassium were abnormal throughout most of the course of the severe COVID-19 patients ( Figure 1 ). It suggested that abnormalities in these indicators can early predict the progression of the severe disease. Lymphocyte and CRP recovery were slow in severe patients ( Figure 1 ). So it must be attention to the balance between early immune response and lateral inflammatory reaction, especially during the first 2 weeks of the course of the disease. The level of D-dimer and BNP gradually increased during the first week of the course of the disease, and reached the peak at day 8-9 of the course of the disease, and then slowly decreased, which suggested that the risk of secondary thrombosis and myocardial injury should be paid attention to during the peak period.