Author: Siggins, Matthew K.; Thwaites, Ryan S.; Openshaw, Peter J.M.
Title: Durability of immunity to SARS-CoV-2 and other respiratory viruses Cord-id: ema81jkp Document date: 2021_4_8
ID: ema81jkp
Snippet: Even in non-pandemic times, respiratory viruses account for a vast global burden of disease. They remain a major cause of illness and death and pose a perpetual threat of breaking out into epidemics and pandemics. Many of these respiratory viruses infect repeatedly and appear to induce only narrow transient immunity, but the situation varies from one virus to another. In the absence of effective specific treatments, understanding the role of immunity in protection, disease and resolution is of p
Document: Even in non-pandemic times, respiratory viruses account for a vast global burden of disease. They remain a major cause of illness and death and pose a perpetual threat of breaking out into epidemics and pandemics. Many of these respiratory viruses infect repeatedly and appear to induce only narrow transient immunity, but the situation varies from one virus to another. In the absence of effective specific treatments, understanding the role of immunity in protection, disease and resolution is of paramount importance. These problems have been brought into sharp focus by the coronavirus COVID-19 pandemic. Here, we summarise what is now known about adaptive immunity to SARS-CoV-2 and draw comparisons with immunity to other respiratory viruses, focusing on the longevity of protective responses.
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