Selected article for: "cascade signal and signal cascade"
Author: Lin, Ling; White, Samantha A.; Hu, Kebin
Title: Role of p90RSK in Kidney and Other Diseases
  • Cord-id: x5xy58d6
  • Document date: 2019_2_23
    • ID: x5xy58d6
    Snippet: The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated protein kinase (MAPK) signalling cascade and is the direct downstream effector of Ras-extracellular signal-regulated kinase (ERK1/2) signalling. ERK1/2 activation directly phosphorylates and activates p90RSK, which, in turn, activates various signalling events through selection
    Document: The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated protein kinase (MAPK) signalling cascade and is the direct downstream effector of Ras-extracellular signal-regulated kinase (ERK1/2) signalling. ERK1/2 activation directly phosphorylates and activates p90RSK, which, in turn, activates various signalling events through selection of different phosphorylation substrates. Upregulation of p90RSK has been reported in numerous human diseases. p90RSK plays an important role in the regulation of diverse cellular processes. Thus, aberrant activation of p90RSK plays a critical role in the pathogenesis of organ dysfunction and damage. In this review, we focus on the current understanding of p90RSK functions and roles in the development and progression of kidney diseases. Roles of p90RSK, as well as other RSKs, in cardiovascular disorders and cancers are also discussed.

    Search related documents:
    Co phrase search for related documents
    • activation cleavage and adaptor protein: 1, 2, 3
    • activation mediate and acute injury: 1
    • activation mediate and acute kidney injury: 1
    • acute kidney injury and lung cancer cell: 1
    • acute kidney injury and macrophage infiltration: 1
    • acute respiratory syndrome and adaptor protein: 1, 2, 3, 4, 5
    • acute respiratory syndrome and lung cancer cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • acute respiratory syndrome and m1 macrophage: 1, 2, 3, 4, 5, 6, 7
    • acute respiratory syndrome and macrophage accumulation: 1, 2, 3, 4
    • acute respiratory syndrome and macrophage infiltration: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • acute respiratory syndrome and macrophage monocyte: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
    • m1 macrophage and macrophage infiltration: 1, 2
    • m1 macrophage and macrophage monocyte: 1, 2
    • m1 macrophage infiltration and macrophage infiltration: 1, 2