Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_106
Snippet: When fitted logistic regressions of seroconversion on recent strains with age at sampling, titer to strain i, titer to strain i-1 and non-normalized summary metric of antibody profiles, positive associations were only found for ATY for all four strains and W 40 for A/Perth/2009, A/Victoria/2009 and A/Texas/2012 (tables S3 and S4). Non-normalized ATY and W40 were less likely to be affected by the pre-birth strains, as individuals are more likely t.....
Document: When fitted logistic regressions of seroconversion on recent strains with age at sampling, titer to strain i, titer to strain i-1 and non-normalized summary metric of antibody profiles, positive associations were only found for ATY for all four strains and W 40 for A/Perth/2009, A/Victoria/2009 and A/Texas/2012 (tables S3 and S4). Non-normalized ATY and W40 were less likely to be affected by the pre-birth strains, as individuals are more likely to have weak but broad cross-reactions to strains that they could not have been exposed to.
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