Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_3
Snippet: Seasonal influenza remains a ubiquitous threat to human health. It is estimated to kill between 291,000 and 645,000 people each year worldwide (1). Through the process of antigenic drift, antigenically novel strains replace previously circulating viruses every few influenza seasons (2) . As a result, people can be infected multiple times over a lifetime (3) . Each of these infections leaves a mark on a person's immune system, and the accumulation.....
Document: Seasonal influenza remains a ubiquitous threat to human health. It is estimated to kill between 291,000 and 645,000 people each year worldwide (1). Through the process of antigenic drift, antigenically novel strains replace previously circulating viruses every few influenza seasons (2) . As a result, people can be infected multiple times over a lifetime (3) . Each of these infections leaves a mark on a person's immune system, and the accumulation of antibody responses over a life course leads to complex individual antibody profiles reflecting both recent and past exposures (3) (4) (5) (6) . A growing body of evidence suggests that the order and timing of influenza exposures shape the immune response in ways that may affect morbidity and mortality (3, 7) , particularly when encountering novel (i.e. pandemic or potentially pandemic) strains (8) , yet a comprehensive quantitative description of how past exposure to multiple strains shapes infection risk remains elusive.
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